Bruker’s rapifleX MALDI-ToF/ToF system has new ToF/ToF optics and smartbeam 10 kHz laser technology, which provide higher speed, better mass resolution and accuracy, and a significantly enhanced MS/MS mass range. The rapifleX can also be used for mass spectrometry imaging offering improved spatial resolution, image contrast and quality, as well as a new ion source for superior robustness and throughput. The laser and ion optics can be dynamically adapted to research or analytical needs. The MS/MS ion optics can be removed from the ion path for imaging, intact protein and peptide applications. Its three-stage grid-less ion reflector is software adjustable to MS/MS and intact molecular weight measurements. A 10-bit digitiser improves dynamic range for quantitative applications.