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Tony (A.N.) Davies is getting excited by GHz NMR. These new high fields offer tantalising new areas of research but at a cost that generally requires their purchase by Government-funded centres of excellence. He argues that continued funding of such projects is essential, especially in difficult economic times.
Nuclear magnetic resonance-based approach to fruit characterisation: the case studies of kiwifruits and peaches
Many analytical methods have been used to control the quality, authenticity and origin of fresh fruit. NMR methodologies yield a comprehensive metabolic profile, provide direct structural information regarding individual metabolites in the mixture and also give information regarding the water state in the tissue. This is useful in discriminating various fruits varieties, in investigating nutritional properties, in monitoring the development of the fruit and in assessing the optimum harvesting time.
Peter Jenks has discovered quantitative NMR. in his article titled “NMR: is it the future for the analysis of organic molecules?”. If only it wasn’t so expensive, it might be the perfect method to certify pure organic compounds.
The Winescreener, a high-performance FT-NMR-based screening system that delivers rapid and cost-effective quantitative targeted and non-targeted statistical analyses of wine, is now available from Bruker. The system features a large number of parameters delivered within a single, completely automated, push-button analysis with minimal sample preparation. Quantification of 25 relevant components is delivered on one measurement and, in addition, both quality and safety are assessed by non-targeted screening. The transferability of the method, based on standard operation procedures, guarantees identical results across different analysis laboratories and, due to its self-learning nature, the solution will further increase its capabilities as new wine analyses are integrated on a global basis.
Benchtop NMR spectrometer that provides identical spectra to standard NMR spectrometers yet weighs only 10½ pounds and costs in the region of US$25,000. Sample volume is 20 µL and the spectrometer is controlled via a web browser. Data can be downloaded for use in any standalone software package.
NMR-based system to measure the influence of additives such as surfactants and dispersants on the particle–liquid interface of nanoparticle dispersants. It can also monitor other changes at the particle–liquid interface such as flocculation.
An affordable electron magnetic resonance system, occupying minimal bench space, which does not require large magnets or cooling systems. Designed for the academic market, it will be offered with a curriculum package for teaching professionals to bring the technique back into laboratories with a modular programme backed with online and written documentation.
A new software tool that provides routine NMR users with seamless support in their daily workflow of spectral interpretation. Assigning the NMR signals to structural characteristics, the software conducts a structural consistency assessment and provides spectral analysis. These results are collected in compact reports to enable easy transfer of information.
Tony (A.N.) Davies is after your advice in his latest column “Your committee needs you!”. The IUPAC Subcommittee on Electronic Data Standards is keen to learn about areas where you would like to see improvements in moving your data between your analytical instruments and data analysis and reporting packages.
The use of nuclear magnetic resonance as an analytical tool in the characterisation of dispersion behaviour
Nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful analytical tools used to probe details of molecular structure and dynamics. It requires very high magnetic fields and, hence, generally uses extremely large, powerful magnets. The advent of small, powerful magnets has allowed much less expensive low resolution NMR instrumentation to be designed, making it feasible to measure commercially important characteristics of dispersion behaviour and performance, including the wetted surface area of particulate suspensions and emulsion droplet size. An important additional practical application is the ability to determine competitive adsorption and/or displacement of polymers and surfactants at interfaces. This article presents a brief overview of these new approaches together with an example of each measurement.
Chemists at the Karlsruhe Institute of Technology (KIT) and the Technische Universität München (TUM) in Germany have introduced an improvement on nuclear magnetic resonance (NMR) measurements for identifying chemical compounds.
A new approach to improving automated analysis of proton NMR spectra through Global Spectral Deconvolution (GSD)
1H NMR spectra are usually interpreted by hand, which is very time consuming, and can become a process bottleneck in fields such as high-throughput NMR. Greater automation of the spectral analysis process has become essential if NMR is to be of value as a high-throughput analytical method in the future.
Metabolic profiling of tissue samples could transform the way surgeons make decisions in the operating theatre, say researchers at a new laboratory. Scientists at Imperial College London, in partnership with clinicians at Imperial College Healthcare NHS Trust, have installed a high resolution solid state nuclear magnetic resonance (NMR) spectrometer in St Mary’s Hospital. Researchers will use the machine to analyse intact tissue samples from patients taking part in studies, to investigate whether it can ultimately give surgeons detailed diagnostic information while their patients are under the knife.
Rapid NMR screening of total aldehydes to detect oxidative rancidity in vegetable oils and decorative cosmetics
Dirk Lachenmeier, Marina Gary, Yulia Monakhova, Thomas Kuballa and Gerd Mildau describe “Rapid NMR screening of total aldehydes to detect oxidative rancidity in vegetable oils and decorative cosmetics”. Lipid oxidation produces rancid products, which are both unpleasant and potentially toxic. The authors describe the use of NMR to screen food and cosmetic products. Whilst, vegetable oils were generally found to be in good condition, German women may wish to be careful of their lipstick, especially if they have had kept it for a while!
UK researchers will gain new insights into vital high tech engineering materials and novel pharmaceuticals thanks to the creation of the UK’s most powerful NMR device for solids now sited in a national research facility in the University of Warwick’s Centre for Magnetic Resonance.
Bruker has introduced the SampleXpress, a robust and cost-effective solution for medium-throughput automation in NMR routine and research applications. Its compact, fully integrated design reduces space requirements and sample transfer times. Combined with a built-in barcode reader for automatic sample identification, SampleXpress is suitable for optimising throughput in standard NMR service laboratories. In addition, efficiency and safety is maximised due to interchangeable, easy-to-fill cassette modules that can be loaded on the bench. The cassettes hold up to 60 standard NMR tubes from 100 mm up to 190 mm with variable diameters from 1.7 mm to 10 mm. The system is compatible with all Bruker Avance NMR spectrometers and can be mounted on all shielded Bruker magnets up to 850 MHz and most non-shielded magnets up to 650 mHz. It is controlled by IconNMR and the barcode identification enables the use of Bruker's laboratory information system, SampleTrack.
Through a combination of remote instrumentation, JPEG-style image compression algorithms and other key enhancements, Alexander Pines and members of his research group have been able to use Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI) to image materials flowing through microfluidic “lab-on-a-chip” devices and zoom in on microscopic objects of particular interest with unprecedented spatial and time resolutions.
In two studies published today in the journal Drug Testing and Analysis, UK and Swiss research teams reveal two techniques proven to identify dissolved cocaine in bottles of wine or rum. These tools will allow customs officials to quickly identify bottles being used to smuggle cocaine, without the need to open or disturb the container.