SCIEX has introduced the ZenoTOF 7600 system, a new accurate mass LC-MS/MS instrument. It includes the proprietary Zeno trap and electron activated dissociation (EAD) fragmentation for the first time in a commercial instrument. Zeno trap pulsing overcomes the traditional duty cycle challenges of orthogonal TOF technology, delivering up to 20× the sensitivity and enabling the routine detection of important low-abundant molecules. In combination, tuneable EAD fragmentation ensures novel structural information can be extracted and quantified from diverse compound types. Compared to previous systems, the ZenoTOF 7600 system can quantify up to 40 % more proteins and analyse samples 5× faster for large biobank studies. In addition, EAD fragmentation brings new capabilities to understand how the proteins are post-translationally modified. The ZenoTOF 7600 can fully characterise an individual lipid from a single spectrum using EAD fragmentation.
