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Proteoform characterisation solution

Bruker’s Proteoform Profiling™ 1.0 solution enables a new life-science research and translational research workflow, i.e. the systematic, large-scale, label-free study of all expressed proteoforms, including protein mutations, splice variants, post-translational modifications, as well as protein processing or degradation products. Detailed proteoform characterisation is of tremendous importance in cell biology and in clinical proteomics research, where traditional bottom-up proteomics analysis of digested proteins scrambles key biological information. While the human genome only has about 25–30,000 coding sequences, or “genes”, for transcription and translation into protein families, the human body may have up to 1 billion different proteoforms expressed.

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