This article describes an application of spectral imaging for the differentiation of tumour and normal cells. The authors also introduce the concept of a spectral barcode, which has had success with some tissues and has potential in others.
This article explains the challenges in pesticide residue analysis of samples associated with suspected poisoning incident investigations, including the wide range of specimens and pesticides that need to be considered.
Thiabendazole (TBZ) is a chemical fungicide and parasiticide used to prevent mould, blight and other diseases resulting from long transportation and storage, largely used as an ingredient in waxes applied to the skins of citrus fruits. The authors describe their work using near infrared-surface-enhanced Raman spectroscopy and conventional Ag nanoparticles, which showed that TBZ was found both on organic fruit and at levels higher than regulations allow.
The single cell Raman spectrum (SCRS) enables cell probing and sorting to study phenotypes and ecophysiology of single cells and explore individual cells in situ in a label-free and non-destructive manner.
In resonance Raman scattering (RRS), the amount of structural and chemical information deduced can be increased by analysing the polarisation of the inelastically scattered light, including the degree of molecular aggregation in bio-molecules in their natural environment.
There are a number of approaches, and by combining FT-IR imaging methodology with microfluidics devices, the opportunity to study live cells by FT-IR imaging in controlled environments is now possible.
Both the size and chemical composition of airborne particles have an effect on human health. Whilst the effects of size have been much studied, many of the toxic chemicals in particles are at very low concentration and have been less studied. Monitoring their composition and concentration over time helps to determine their source. Synchrotron radiation-induced XRF spectrometry proves to be a good tool for this purpose.
This article shows that pyrolysis techniques, in combination with spectroscopy, are helping our understanding of how the organic matter in our solar system came to be. Fascinatingly, they also show how secondary processing of meteorite materials seems to enhance the abilities of atmospheres to host life on planetary surfaces as well as providing the raw materials from which life could originate.
The use of isotope ratio mass spectrometry is on the rise, with more papers published and more labs with the facilities. The authors describe the main IRMS studies conducted on seeds and isotopes and outline the most important aspects of the use of seeds to study plant eco-geochemistry and plant material traceability.
The presence of “particles” in protein pharmaceuticals (biologics) can cause severe, unwanted effects in the drug. The article describes the use of mid-infrared micro-spectroscopy for the investigation and chemical characterisation of single particles in these biologics.