Michael A. Bernstein
Process Analytical Technology (PAT) is a US Food and Drug Administration (FDA) initiative to improve drug substance manufacturing. Control over production processes and impurity production are key elements. These lead to more robust and cheaper production processes, facilitate predictable scale-up and technology transfer and more effectively manage the risk.
Sara Castiglioni,* Ettore Zuccato, Chiara Chiabrando, Roberto Fanelli and Renzo Bagnati
In recent years, the environmental fate of therapeutic drugs used by humans and animals (environmental pharmacology) has increasingly become recognised worldwide as an emerging issue. After administration, drugs can be excreted in high percentages as the parent compound and/or active metabolites in urine and faeces and reach wastewater treatment plants (WWTPs) and then be released into surface waters, soil and sediments.
Bernd W.K. Diehl,a Frank Malzb and Ulrike Holzgrabec*
aSpectralservice, Emil-Hoffmann-Str. 33, 50996 Köln, Germany
bFederal Institute for Materials Research and Testing (BAM), Richard-Willstätter-Str. 11, 12489 Berlin, Germany
cInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany
Quantitative (q) methods in nuclear magnetic resonance (NMR) spectroscopy have been used successfully for many years. However, there is a lack of general acceptance of qNMR in the pharmaceutical industry, whereas chromatographic methods are well established and documented in analytical standards, pharmacopoeia and drug master files.
Anna-Stiina Jääskeläinena and Tiina Liitiäb
Papers are susceptible to colour changes during storage. This is easily seen as a yellowish or brownish colour of old printed materials, such as old books and newspapers. It is important to identify the reactions causing yellowing, as some of those take place quickly after papermaking and that way decrease the value of the material. Furthermore, understanding the reactions and mechanisms of ageing would help in choosing the correct storage conditions for historical documents.
Neil A. Macleod, Charlotte Eliassona and Pavel Matousek*
apresent address: PeTek Oseberg South, Hydro, Sandsliveien 90, postboks 7190, 5020 Bergen, Norway
A number of analytical applications in the area of security screening, medical diagnosis, drug authentication and quality control often require non-invasive probing of diffusely scattering (turbid) media in order to obtain chemical characterisation of deep-lying sample regions. Examples include non-invasive disease diagnosis, the detection of concealed explosives and illicit materials, the identification of counterfeit drugs and quality control applications in the pharmaceutical industry.
- Combined infrared and visible spectroscopic ellipsometry study of thin polymer layers
- Quantitative surface chemical microscopy by X-ray photoelectron spectroscopy
- The analysis of used lubrication oils by inductively coupled plasma spectrometry for predictive maintenance
- X-ray fluorescence trace metal analysis of environmental liquid samples after membrane preconcentration
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Gujarathi Dipak B. saidSir,
This is an excellent appl... 1 year ago
Rakesh Kanda saidDr Alfonso,
Matrix suppression is ... 2 years ago
Dr Robson JCF Afonso saidDear Authors,
As you sad atmospheric... 2 years ago
firstname.lastname@example.org saidNice article.
Based on this article ... 2 years ago
Dr Robson JCF Afonso saidI am glad to hearing someone question... 2 years ago
- Atomic absorption
- Atomic emission
- Ion mobility
- Laser spectroscopy
- Mass spectrometry
- Near infrared
- NMR ESR EPR
- Related equipment
- RMs and standards
- Sample prep
- Separation science
- Surface analysis
- X-ray spectrometry